Representative render — packaging may vary
Rapamycin
Also indexed as Sirolimus · AY-22989 · mTOR inhibitor
All products currently listed on this site are for research purposes only.
A macrolide isolated from Streptomyces hygroscopicus and the defining chemical probe of the mTOR pathway.
Size
$189.00
per unit · EP-RPM-030
Add 1 more to reach $172.00 per unit.
| Quantity | Unit price | Saving |
|---|---|---|
| 1–1 | $189.00 | — |
| 2+ | $172.00 | 9% |
| 5+ | $155.00 | 18% |
Certificate of analysis
Lot EP-RPM-2605A
98.9%
Assayed purity
Guaranteed floor 98.5%
- Tested
- May 15, 2026
- Laboratory
- Colmaric Analyticals
- Methods
- HPLCLC-MS
Literature
Research context
Rapamycin forms a ternary complex with FKBP12 that inhibits mTORC1. It is the compound that named the target, and remains the reference inhibitor in autophagy induction, protein-synthesis and cellular-senescence assays. The Interventions Testing Program lifespan data in mice is the most-cited result in the pharmacological senescence literature.
Documented research areas
- mTORC1 inhibition via FKBP12
- Autophagy induction in cell culture
- Cellular senescence and SASP research
- Lifespan studies in genetically heterogeneous mice
Specification
Chemistry
- CAS number
- 53123-88-9
- Molecular formula
- C51H79NO13
- Molecular weight
- 914.17 g/mol
- Form
- Capsule
- Purity floor
- ≥ 98.5%
- Appears in
- 4 documented research areas
Laboratory
Storage and handling
Storage
Store sealed at -20°C, protected from light and oxygen. Light- and oxidation-sensitive.
Handling
For laboratory use by qualified personnel only. Not for human or veterinary use.
Research use only. This material is supplied for laboratory research by qualified personnel. It is not a drug, food, cosmetic or household product, and it is not for human or veterinary use. See our research use policy and prohibited uses.
Sources
Selected references
- Harrison et al., Nature (2009) — Rapamycin fed late in life extends lifespan in mice
- Laplante & Sabatini, Cell (2012) — mTOR signalling in growth control
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Nearby
Studied alongside
- Incretin & Metabolic
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5-amino-1-methylquinolinium
A quaternary quinolinium small molecule described in the literature as a selective inhibitor of nicotinamide N-methyltransferase.
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Incretin & MetabolicMOTS-c
Mitochondrial ORF of the 12S rRNA type-c
A sixteen-residue mitochondrial-derived peptide encoded in the 12S rRNA region, central to the retrograde-signalling literature.
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NMN
Nicotinamide mononucleotide
The immediate biosynthetic precursor to NAD+ in the salvage pathway, and the most-studied NAD+ intermediate in rodent senescence work.
Lyophilized powder≥99% purityLot assayed 99.4%From
$89.00
1 size
Research Use Only